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1994-10-25
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Document 3050
DOCN M94A3050
TI Delayed type hypersensitivity skin testing in HIV-infected persons,
Chiangrai, Thailand.
DT 9412
AU Yanai H; Uthaivoravit W; Sawanpanyalert P; Limpakarnjanarat K; Mastro
TD; Chiangrai Health Club, Muang Chiangrai, Thailand.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):165 (abstract no. PB0086). Unique
Identifier : AIDSLINE ICA10/94369525
AB OBJECTIVE: To examine the utility of delayed type hypersensitivity (DTH)
skin tests in HIV-infected individuals in Chiangrai, northern Thailand.
METHODS: We examined the reactivity to three DTH skin test antigens
(PPD, Mumps, and Candida) in 201 asymptomatic HIV-infected individuals
identified among blood donors and anonymous HIV counseling and testing
clinic attendees; and 102 HIV-seronegative blood donors. RESULTS: Latent
TB infection (PPD > or = 10mm induration) was common among HIV-negative
persons: 70% among those with, and 54% among those without a BCG scar.
Compared to HIV-negatives, HIV-positive persons had decreased (P < 0.01)
reactivity to all three antigens: TABULAR DATA, SEE ABSTRACT VOLUME. CD4
level and skin test reactivity show only small correlations. DISCUSSION
AND CONCLUSIONS: Mumps and Candida are appropriate antigens for anergy
testing in Thailand and can be used as a functional measurement of
immunity, in addition to CD4. The high prevalence of latent TB in this
population and decreased reactivity to PPD in HIV-seropositives support
the provision of INH preventive therapy to all HIV-infected individuals
in Thailand regardless of PPD results.
DE Antigens/DIAGNOSTIC USE/IMMUNOLOGY Blood Donors *Developing Countries
Human Hypersensitivity, Delayed/*IMMUNOLOGY HIV
Infections/DIAGNOSIS/*IMMUNOLOGY HIV Seronegativity/IMMUNOLOGY
*Intradermal Tests Leukocyte Count Reference Values Thailand T4
Lymphocytes/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).